Carboprost (Hemabate) is contraindicated in patients with which condition?

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Carboprost is a prostaglandin that stimulates uterine contractions to control postpartum hemorrhage. A key effect is bronchoconstriction, so giving it to someone with asthma or significant bronchospasm can trigger severe respiratory distress. For this reason, asthma or bronchospasm is a true contraindication. The other conditions listed don’t carry the same immediate risk of life-threatening bronchospasm, so they aren’t the reason carboprost is avoided. In patients with asthma, alternatives for controlling hemorrhage are chosen to avoid provoking airway constriction.