Which drug is first-line for preventing or treating PPH after delivery?

• A. Misoprostol.
• B. Carboprost.
• C. Oxytocin.
• D. Methylergonovine.

Answer: (C)

Oxytocin is used first because it directly stimulates uterine contractions, promoting firm uterine tone and helping to prevent or stop postpartum bleeding from uterine atony. It acts quickly and has a short duration, making it easy to titrate and monitor for effectiveness and adverse effects. This favorable safety profile and strong efficacy in reducing bleeding after delivery make it the initial drug of choice for both prevention and early treatment of post‑partum hemorrhage. If bleeding continues despite adequate oxytocin, other uterotonics can be added or used as alternatives, but they carry more specific risks or contraindications.