Which medication is generally avoided during breastfeeding due to risk to the infant?

• A. Acetaminophen
• B. Ibuprofen
• C. High-dose aspirin
• D. Acetaminophen with codeine

Answer: (C)

When a mother breastfeeds, medications can pass into breast milk and affect the infant. High-dose aspirin is avoided because salicylates transfer into milk and can interfere with the baby’s blood clotting and GI lining; the risk increases with higher doses, making it unsuitable for nursing infants. In contrast, acetaminophen and ibuprofen are generally considered safe for short-term use during breastfeeding at typical doses. A product that combines acetaminophen with codeine is avoided because codeine can be converted to morphine in some babies, potentially causing sedation or respiratory problems.